Family genetic studies

Family genetic studies.

Genetic and genomic discovery using family studies.

Genetic studies traditionally have been performed on sets of related individuals, that is, families. Mendel’s early studies in sweet peas (Pisum sativum) on the inheritance patterns of discrete traits from parents with specific mating types to offspring has shed light on the basic mechanisms of inheritance, including the fundamental laws of segregation of discrete factors (genes) from parents t...

Family based studies and genetic epidemiology: theory and practice.

Family based studies have underpinned many successes in uncovering the causes of monogenic and oligogenic diseases. Now research is focussing on the identification and characterisation of genes underlying common diseases and it is widely accepted that these studies will require large population based samples. Population based family study designs have the potential to facilitate the analysis of...

Spanish version of the Family Interview for Genetic Studies (FIGS).

INTRODUCTION The use of the Family Interview for Genetic Studies (FIGS), has made it possible to advance in the performance of family studies for research in genetic psychiatry. This study aimed to adapt this interview into Spanish and develop a validation process of the FIGS in a sample of Cuban families with a family background of schizophrenia. METHODS The English version of the FIGS was t...

Family-genetic studies of psychiatric disorders. Developing technologies.

During the past decade new concepts and technologies have improved the conduct of family-genetic studies in psychiatry. We compiled and critically evaluated these advances, including study design, pedigree collection, diagnostic procedures in adults and children, and epidemiologic and genetic approaches to data analysis. These approaches have improved the collection of accurate information on t...